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Secretion of cytotoxic granules is the dominant mode of cytotoxicity associated with NK cells.
Interestingly, the compound concentration increases nature of cytotoxicity also increasing.
However, compounds 1 and 3 were devoid of cytotoxicity.
Lack of cytotoxicity has been confirmed by MTT assay.
In fact, the kinetics of cytotoxicity and the IC50 values were dependent on the target cells.
DNA fragmentation assay showed fragmented bands indicating that the mechanism of cytotoxicity is through apoptosis.
Open image in new window Fig. 3 The measure of cytotoxicity of a compound.
ILC1s have similar features to conventional NK cells, aside from their lack of cytotoxicity.
Figure 12 Distribution of cytotoxicity scores generated from Pfizer model (combined IC50 and Pct inhibition).
The level of the secreted TNF-α correlated with the rate of cytotoxicity well.
Mechanism of cytotoxicity appears to involve the generation of singlet oxygen inside the cell.
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