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Our findings can guide the design and spatial targeting of control interventions against helminth infections in Eryuan county.
Types of control interventions considered in this review included no treatment (wait-listed or treatment as usual), placebo-controlled (sham acupuncture, minimal acupuncture or non-invasively controlled), pharmacological treatment (standard medication to treat obesity) or nonpharmacological interventions (such as dietary or physical activity interventions).
In such a context, mathematical models provide invaluable tools to explore and understand the dynamics of T. cruzi transmission, and to design, optimize and monitor the efficacy of control interventions.
It identifies peculiarities of dry eye disease that complicate clinical trial design, such as the lack of correlation of signs and symptoms, as well as the likelihood of control interventions having a lubricant (placebo) effect.
Such experiments, coupled with models like ours, would help with the assessment and design of control interventions.
In that way models can yield insight into how the effectiveness of control interventions varies between different vector-pathogen systems.
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When public outrage does ensue, another mechanism of control — intervention by senior officials — sometimes occurs.
Although this approach can make the choice of control intervention more straightforward, the design of a treatment protocol for acupuncture and related therapies is more challenging because it includes a wide variety of techniques38.
The most frequently reported items (reported ≥70% of the time) were A1 (statement on style of acupuncture), A2 (rationale), B4 (description of location of points) and F18 (intended effect of control intervention).
First, we included only one type of control intervention – sham acupuncture at a non-acupuncture point.
Trials comparing BVA with any type of control intervention were also included.
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