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There can be no way of concluding with certainty that Darwin had by then become a 'transmutationist' but it is clear from his notes that he was actively contemplating the possibility as early as late 1832.
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The limited extent of our diagnostic procedures prevent us from concluding with certainty that VEEV infection was the main cause of death.
While it is always difficult to conclude with certainty that convergence of the MCMC has occurred, it is possible to infer with some degree of certainty that convergence has not occurred (Kuhner 2009).
However, our data do not allow us to conclude with certainty about the origin of the modifying factor(s) from either of the genetic backgrounds since it could be the result of a spontaneous mutation in any of the alleles.
Without any other validating measures it is not possible to conclude with certainty that the information generated is an accurate representation of substance use in this population.
This result suggests that our approach tends to slightly underestimate the number of expressed genes, but with only four positive controls, it is difficult to conclude with certainty to what extent false negatives are produced.
Furthermore, in the absence of a complete C. mesostigmatica nuclear genome sequence, it is presently not possible to conclude with certainty that the host nuclear genome does not possess at least some of the missing proteasome genes.
Previous reviews of interventions to reduce inappropriate prescribing/polypharmacy in older patients have not been able to conclude with certainty that multifaceted interventions are more effective than single strategies.
It is thus not possible to conclude with certainty which phenomenon that drives the other.
It is therefore impossible to conclude with certainty that the observed changes in selection during 2004 arose solely due to drought, rather than our manipulation of the male lizard population.
However, this study has the limitation of a considerable loss to follow-up, predominantly in the non-operatively treated group, which makes it impossible to conclude with certainty that plate fixation is preferred over conservative treatment in active adults.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com