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However, the effective functioning of GP is often affected by its nature of producing the models of complex size.
Site-directed mutagenesis of human αB crystallin demonstrated that chaperone activity was independent of complex size and that chaperone activity required exposure of the same interactive domains on the surface of αB crystallin that were used in assembly [26], [27], [29], [31], [37].
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It has been noted that the distribution of complex sizes follows a power law distribution [ 7], meaning that a large majority of complexes are small.
We then randomized the assignment of subunits to protein complexes 100,000 times (but keeping the distribution of complex sizes the same) to calculate the expected frequency of complexes in each bin.
The overlap between each complex and a functional module was identified and the degree of overlap to complex size was calculated.
Figure 3 Performance of reduction of simplicial complex size.
(E – F ) Velocity, run length and their standard deviations as a function of the complex size for different values of k s t i f f.
(H – I ) Velocity, run length and their standard deviations as a function of the complex size for best parameters of the complete model.
Namely, we model local material strength using an autocorrelated random field attempting to capture a statistical part of the complex size effect, scatter inclusive.
We illustrate the transformation with a toy example in Figure 2. Figure 2 Reduction of simplicial complex size.
It is only in the realistic case of a more complex size and spatial distribution of bubbles that complex ash particles are expected to form.
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