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Meanwhile, data from randomised trials confirm the results of former observational studies, demonstrating that hemicraniectomy not only significantly reduces mortality but also significantly improves clinical outcome without increasing the number of completely dependent patients.
In 2007, the results from nonrandomised studies were confirmed by a pooled analysis of three randomised controlled trials, supporting the widespread opinion among experts that hemicraniectomy in malignant MCA infarction not only reduces mortality but also leads to an improved outcome of the survivors without increasing the number of completely dependent patients [ 133].
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Measures of sensitivity and, in particular, specificity, are of course completely dependent on the test data used.
This provides a total possible score of 6 (which represents independent mobility) to the maximum score of 70 (completely dependent) (see Additional file 1: Basic Mobility Scale).
A score of 1 (completely dependent), 2 (requires assistance) or 3 (completely independent) is assigned for each of the six areas, with scores ranging from 6 (completely dependent) to 18 (completely independent).
We found that localization of POLβ to sites of irradiation was completely dependent on XRCC1, while the recruitment of PNK, PCNA, and PARP-1 were enhanced in the presence of XRCC1 or overexpressed human XRCC1-EYFP (Table I).
The physiological effects of progesterone are completely dependent on the presence of the human PGR, a member of the steroid-receptor superfamily of nuclear receptors [ 25].
As demonstrated in the progesterone receptor knockout mouse, the physiological effects of progesterone are completely dependent on the presence of its receptor gene, PGR, which exists as a single-copy gene.
This early wave of apoptosis is completely dependent on the nuclear accumulation of p53.
The value of product is completely dependent upon obtaining a leading share of its market before the growth slows".
The value of product is completely dependent upon obtaining a leading share of its market before the growth slows [43, p. 35].
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