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Treated analysis is considered as high risk of complete outcome data bias, therefore the results of the assessment shows this element as a separate item for additional clarity.
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This database provided 9160 weeks of complete outcomes data.
For the first 8 weeks of sorafenib therapy, the database from the Escudier et al., trial provided 3608 weeks of complete outcomes data.
Consideration may be needed to offering adequate reimbursement for the time and trouble of completing outcome measures (Williams et al. 2014).
We have used four criteria from The Cochrane Collaboration's tool for assessing risk of bias 15: blinding of outcome assessment, complete outcome data such as missing data, selective reporting such as not reporting prespecified outcomes and other sources of bias such as bias related to the specific study design and competing interest.
In summary: the current quantitative methods seem to be more of an explanatory way of summarizing the available evidence, instead of quantitatively summarizing complete outcome prediction models.
Table 1 shows comparisons of children with complete outcome data who were included in this analysis or excluded because of missing covariate or exposure data.
Two authors (SP and TV) independently assessed risk of bias using standard Cochrane criteria, including allocation concealment, random sequence generation, blinding of participants and personnel, complete outcome data and absence of reporting bias.
Because generic and condition-specific measures have different strengths and are conceptually distinct, it is often recommended to administer both types of instruments as part of a complete outcomes assessment in clinical trials [ 5, 17- 19].
This report reinforces the value of following patients until complete outcome stability.
A number of trials did not present complete outcome data, using available case analyses rather than including all randomized participants.
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