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In order for a new regimen to be licensed, it will be necessary to demonstrate that it is of comparable efficacy to the standard regimen.
It is very unlikely better results can be achieved with new drugs, a clinically more relevant goal would be a regimen of comparable efficacy to standard treatment but of substantially shorter duration.
They are of comparable efficacy to the Mayo regime but with less toxicity (Carmichael et al, 2002; Douillard et al, 2002; Twelves et al, 2005).
It must be noted that the 6-week regimen of itraconazole is of comparable efficacy to griseofulvin, in cases of Microsporum-TC.
Some researchers have claimed [ 8] that atypicals are of comparable efficacy to typical antipsychotics of medium or low potency, because lower-potency antipsychotics have a more favorable EPS profile, and thus provide greater tolerability and better outcomes.
A phase III trial showed the oral formulation to be of comparable efficacy to injected pentamidine; however, an extended phase I safety trial using 14 day dosing (instead of the successful 10 day dosing in the phase III trial) demonstrated unacceptable nephrotoxicity and development was halted.
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All pol II- expressed shRNA variants induced mild inhibition of Luciferase reporters carrying specific targets and none of them showed comparable efficacy to their polymerase III-expressed H1-shRNA controls, regardless of hairpin position and termination signal used.
Randomized trials have proven the safety of neoadjuvant chemotherapy with comparable efficacy to adjuvant chemotherapy.
These findings might be due to the nonchemotherapeutic nature of erlotinib, which shows comparable efficacy to chemotherapeutics coupled with a more favorable tolerability profile (see also Table 2).
The results for the analyses of all secondary efficacy endpoints were consistent with those of the primary endpoint, with lipegfilgrastim demonstrating comparable efficacy to the active comparator pegfilgrastim.
Two of these publications referred to one single-arm study of Gemcitabine with Carboplatin that resulted in safe, tolerable uptake of this regimen with a comparable efficacy to cisplatin-based regimens [ 35, 36].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com