These common strain effects suggest the possibility of common modifier(s) across multiple biochemical modalities and thus potential targets of broad therapeutic appeal.
Because physiology depends on disease state, we hypothesized that the effects of another common modifier of physiology, drugs, would be apparent when visualizing physiological correlation networks and comparing the cases of the drugs being given or not.
Lehner, B., Crombie, C., Tischler, J., Fortunato, A. & Fraser, A. G. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
This finding suggests that genes with expression associated with BRCA1 and BRCA2 mutation status are enriched for the presence of common genetic modifiers of breast cancer risk in these populations.
In our alternative RECODE-R hierarchy of classification, we considered SGA as a common modifier of other underlying maternal and fetal conditions, but not as a specific condition in itself, unless SGA was isolated.
Despite this, CLCR remains a common modifier of drug dosing in clinical practice, with recent data suggesting important pharmacokinetic [ 11, 12], and clinical [ 21] implications.
While their preliminary data indicate that there is no single common modifier responsible for the variation in tumor burden, genotyping in an additional cohort of extreme subjects to confirm or refute its modifier status is ongoing.
Another type of exception to the general rule of independence between background mortality and cause-specific mortality would be the existence of any common causal modifiers of m, fX and fC, for example, the allocation of health-care expenditure.
As he said (Montague 1970a, 218), this made it possible to deal with the semantics of common phenomena such as modifiers, e.g. in Necessarily the father of Cain is Adam.
Because measurement error in covariates is also important, we consider the problems in measurement of common confounders and effect modifiers.
