Recent successes in reprogramming cells for regenerative medicine purposes via ectopic TFs have been achieved largely by educated guess about which TFs needs to be over-expressed combined with systematic, brute-force trial and error ectopic expression of combinatorial sets of relevant TFs (see below).
Similarly, an analyst can identify the optimal medium for culturing a particular cell (iPS or cancer cell) using an MMV of a combinatorial set of factors (generated by the 2N method).
This approach can naturally deal with multiclass data while some of the more advanced classifiers, such as support vector machines (SVM) [ 28], require the bridging of results from a combinatorial set of such classifiers to simulate multiclass parameters [ 20].
To reduce the number of alternatives considered in a combinatorial set, the concept of using spatial distance to represent the significance of the item to the player in a non-zero-sum game can be implemented.
This representation describes the combinatorial set of parts interactions in polynomial space.
A full system would include a combinatorial set of partially assembled scaffold complexes, and contain both fast-paced and slow reactions.
Mei and colleagues [ 33] published a very extensive study in which ESCs were plated on a combinatorial set of substrates and adsorbed proteins.
Using the comprehensive nonredundant protein database, we first examined "availability" of all possible combinatorial sets of 8,000 triplet species.
It is widely accepted that the installation, maintenance and functional output of epigenetic modifications occur in concert via combinatorial sets of modifications.
Post-translation histone modifications and the various combinations thereof have been proposed to "write" the "histone code" creating extensive diversity through such combinatorial sets of modifications for the recruitment of distinct regulatory proteins and complexes [24].
