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Overall the alterations in the metabolome detected in this study as associated with PCa bone metastases indicated disturbed molecular and cellular functions of clear relevance for cancer progression.

As EPHESUS compared eplerenone plus standard therapy with standard therapy alone, the results are of clear relevance to current practice.

The thoughtful handling of such issues is of clear relevance to the maintenance of public trust in the research process.

22 The review also recommended that trials should be framed and organised in ways that minimise differences between research and clinical practice, using simple and clear entry criteria, and address questions of clear relevance to clinical practice.

Similar(56)

Third, the value of historical and contextualising analyses that unsettle the prevailing policy discourses has been demonstrated by a small number of scholars, but such work is scarce in spite of its clear relevance to India's relationships with global forces.

In summary, two of the three known members of the hAG family of proteins show clear relevance to breast cancer that is strengthened by their roles in Xenopus development, a significant association with ER, and putative protein-binding partners that are not only linked with cancer progression but provide opportunities for those interactions to be targeted in the development of cancer therapies.

As such, an extrapolation of data is needed but as markers of glomerular hyperfiltration, clear relevance to the CKD and particularly the diabetic nephropathy population is apparent.

However, despite the clear relevance of merlin in neuronal cells of the PNS, a functional role for merlin in CNS neurons remains elusive.

Although we have not seen a clear relevance of salivary flow with the amount of water consumed and with the antibodies apparent in the serum, it is possible that antibodies such as anti-M3RP and anti-α-fodrin antibodies may have a role in the salivary flow decrement.

Turnover has long been a topic of organizational research with clear relevance to practice, given the costs that turnover imposes on organizations in terms of loss of key employees, and given increasing evidence that turnover is negatively related to organizational performance (Shaw et al., 2009).

The clear relevance of the mouse model was demonstrated in human patient material, where an increased expression of monomeric TRAP, but not proteolytically processed TRAP, was apparent in adipose tissue of obese subjects.

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