Finally, we circle back to the rise in inequality that is a root cause of the chronic demand shortfall.
For example, a decreased demand for B cell production in aged mice due the accumulation of long-lived cells may lead to selection of slow cycling HSCs, whereas a chronic demand for B cells enforces continuous B cell production and this may select for rapid cycling HSCs.
The chronic demand shortfall has lots of implications.
Rgs16::GFP was reactivated, first in ducts, then islet β-cells, under conditions of chronic insulin demand or hyperglycemia in mouse models of type 1 and type 2 diabetes, and during gestation.
In simple terms, what has caused the chronic demand shortfall?
You've probably heard of this debate – former US treasury secretary Larry Summers has borrowed the term "secular stagnation" (from economist Alvin Hansen) to describe this chronic demand shortfall.
Therefore, late access of patients led to this inpatient rehabilitation program which mixes sub-acute interventions (strategies designed to enable recovery of impairments, compensation of disabilities and preventive techniques), and chronic demands (work focused on social re-entry, community and domestic functional independence, and the reduction of handicaps).
We conclude that the widespread implementation of GP copayments would disproportionately burden lower-income families, who experience higher rates of chronic illness, higher demand for GP services, and lower capacity to absorb price increases.
The nature of chronic disease further demands longitudinal and prospective assessments since the symptoms of chronic disease may not appear until years after exposure to an infectious agent.
Limiting the numbers of chronic HIV cases demands an active engagement with effective prevention, to reduce the numbers of new cases who will need ART in a few years.
