Two examples are staufen-1 (STAU1) mediated decay (SMD) and the decay of certain replication-dependent histone mRNAs at the end of S-phase of the mammalian cell cycle [ 27- 29].
In certain replication studies [ 106], the number of participants was too small and the functional relevance of the identified polymorphisms remains unclear.
These examples suggest that by K-3, msh5-22 cells have already encountered problems in DNA replication and in response have up-regulated transcription (or down-regulated mRNA degradation) of certain DNA replication and repair genes.
More recently we showed that archaeo-eukaryotic type primases (and prim-pol proteins with both primase and DNA polymerase activity) also contain a derived version of this fold, which is further related to DNA-binding domains of certain viral replication initiation proteins and the catalytic domain of rolling circle replicator tyrosine recombinases [ 5].
Furthermore, the activity of certain sequences as replication origins in mammalian cells correlates with local differences in gene expression in different cell types or lineages [ 16- 19].
This effect mediated by the expression cassette may not only be harnessed to inhibit wt adenovirus replication but also to prevent the replication of certain adenoviral vectors commonly used in gene therapy studies.
The reliability and replicability of the NHL model is seen in the replication of certain deficits across multiple sites, such as prepulse inhibition deficits and hypersensitivity to dopamine agonist-induced attenuation of prepulse inhibition [ 189, 195- 198].
There Alberts investigated the role of certain proteins in chromosomal replication and served as department chairman (1985 90).
Likewise, elegant studies over the last years have identified endogenous cofactors such as phospholipids or polyanions that promote replication of certain prion strains in vitro 25, 26.
Remarkably, several ISGs, such as ADAR, family with sequence similarity 46, member C, lymphocyte antigen 6E and mucolipin-2, can enhance the replication of certain viruses.
Applying the FISH replication assay to biallelically expressed genes in cells of cancer patients indicated that malignancy is associated with non-disease-specific loss of the normally synchronous pattern of replication of certain loci.
