Sentence examples for of cerebellar development from inspiring English sources

The results support our hypothesis that AAH is an important mediator of cerebellar development and function, and link AAH expression to Notch signaling pathways in the developing brain.

Mitogenic signaling by the Sonic Hedgehog (Shh) pathway is critical for GNP proliferation and expansion of the EGL in the post-natal period of cerebellar development [9], [10], [11].

From as early as E18.5 until the end of cerebellar development at postnatal stage P21, cerebellar morphology of the mutants substantially differed from that of control animals, particularly in its size, cerebellar cortical folding and lamination.

Shh signaling is down-regulated in GNPs at the later stages of cerebellar development through a mechanism which is not well understood, and this failure of GNPs to respond to Shh correlates with their cell cycle exit and subsequent differentiation into mature GC neurons that migrate inward to form the IGL [4], [5].

First, studies of cerebellar development have shown that Purkinje cells are already committed to their adult phenotype at around their time of birth in the 4th ventricle (E10 E13: 6, 8) and that subsequent experimental manipulations cannot alter this [e.g., 53], [54], [31]: [reviewed in 11], [40].

Our findings suggest that PEX13 deficiency leads to mitochondria-mediated oxidative stress, neuronal cell death and impairment of cerebellar development.

Here, we took advantage of a unique hypomorphic Mdm2 allele (Mdm2puro) to examine the contribution of this ubiquitin ligase to cerebellar development in the presence of its target, wild-type p53 [38].

Survivors frequently show a broad range of disabilities connected to cerebellar development, such as hypotonia, fine motor coordination failures, ataxia, impaired motor coordination sequencing and cerebral palsy (Haldipur et al., 2011; Limperopoulos et al., 2005; Volpe, 2009).

In light of several devastating malformations of human cerebellar development affecting posture, balance, and motor learning [ 5– 8], the molecular and genetic mechanisms of cerebellar lamination and foliation have been topics of intense investigation.

Greater knowledge of the cellular and axonal anatomy of heterotopia of the PF has important implications toward our understanding of normal cerebellar development as well as cerebellar disorders with defective neuronal migration and altered lamination.

In this study, the orientation of dividing GNPs at different stages of postnatal cerebellar development has been characterized.