While discussions of drug diversion are often framed in terms of broad, population-level patterns and demographic trends, the present analysis provides a complementary sociocultural perspective that is attuned to the local and everyday phenomena.
Transcriptome studies generally have been considered too expensive to be used for this kind of broad population sampling, but as they becomes increasingly cost effective, investment in deeper sampling of individuals promises to be fruitful for robust population genomic studies.
There were three main parts to the data collection: a survey of bat-human interactions, interviews of broad population samples and targeted interviews of people engaged in bat-related activities.
A randomised control trial, with a co-existing cohort, would not be feasible in this type of broad population intervention, as both participants and health care workers move or communicate with each other introducing contamination of the control group.
Analyses that identify (and distinguish between) neglected subsets, such as persons who have clinical deficiency or malabsorption, may mitigate distortion and add valuable depth to the flat landscape of broad population analyses.
Other reports have suggested that while smoking initiation rates may be higher in disadvantaged groups, smoking cessation rates are equal in all groups, although these reports tend to rely on coarse measures, and flawed interpretations of broad population measures.
Although participants' perceptions of DE learning experiences may be illustrative and/or indicative of broader trends, qualitative epistemology restricts extrapolation of findings beyond the present sample and aims to examine emerging themes in-depth rather than be quantitatively representative of broader populations (Cohen, Manion, & Morrison, 2007; Neuman, 2011; Ragusa, 2012).
A recent meta-analysis found that the evidence for antiplatelet agents in patients with CKD was of low quality, being frequently derived from post hoc analyses of trials of broader populations [ 46].
22, 23 While RCTs are designed to eliminate confounding factors and maximize internal validity, the results of well-conducted observational studies of broader populations are more applicable (ie, generalizable) to patients seen in general practice.
Sampling in these locations promises the protection of broader populations, including those who suffer from conditions not targeted for massive global health investments, or those not able to afford to pay for guaranteed quality in legal pharmacies.
