Sentence examples for of broad modification from inspiring English sources

We surveyed various epigenetic phenomena, including focal peaks, areas of broad modification, and bivalent promoters.

Whether the experimentally observed broad modification of these regions is due to DNA looping and nucleosome wrapping or the proposed spreading mechanism needs to be further investigated.

We establish the transcriptional relevance of a difference in an H3K9me3+ broad modification in that it affected transcription of CACNG7.

We verified that a change in a broad modification affected gene expression of CACNG7.

We use the term "broad modification" to denote long regions of chromosomal space in which there is a given epigenetic modification present continuously (>50 kb), as opposed to focal regions of modification ("peaks") in a promoter or other region.

Overall, our "core set" data establishes sets of potential therapeutic targets, but the diversity in sets of sites and broad modifications among cell types underscores the need to carefully consider BTSC subtype variation in epigenetic therapy.

Unfortunately, this array format only covers a portion of the genome, hence, it will be necessary to use other methods, most likely ChIP-seq, to fully establish the prevalence of differences in broad modifications for this mark across different cell types.

Broad modifications of various positions of the minimal natural epitope recognized by the myelin-associated glycoprotein (MAG), a blocker of regeneration of neurite injuries, produced sialosides with nanomolar affinities.

We found that "broad modifications", large areas of genomic space possessing an epigenetic mark (operationally defined as peaks >50 kb), also showed marked differences in presence or extent among cell types.

These broad modifications are prevalent in the human genome [ 16].

The work will be of broad interest with modifications as described here.