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Thus, the extracts of bioactive plants, with their known beneficial and remedial effect, is an important area of investigatation for anti-breast cancer agents.
The use of bioactive plants, traditional herbal or ethnoveterinary medicine may present economical and sustainable alternative if greater understanding of the mechanism, interaction with other nutrients, and level of toxicity can be achieved.
In Pakistan, a vast diversity of bioactive plants grown naturally.
The medicinal ethnobotanical knowledge of Native Americans has been an important source for the identification of bioactive plants, and studies show a high degree of correlation between traditional medicinal uses and observed biological activity [ 5].
In conclusion, this study has demonstrated the successful streamlining of the screening process of bioactive plants with anticancer activity, by eliminating poor candidates on the basis of cytotoxic criterion that takes into consideration effective dosage.
In spite of the recent domination of the synthetic chemistry as a method to discover and produce drugs, the potential of bioactive plants or their extracts to provide new and novel products for disease treatment and prevention is still enormous [ 1].
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A plethora of bioactive plant metabolites has been explored for pharmaceutical, food chemistry and agricultural applications.
In spite of the importance of these enzymes for the synthesis of bioactive plant secondary metabolites, only two plant P450 structures has been obtained to date.
Hence, this report demonstrates that pathway engineering in yeast through transforming the subcellular morphology rather than altering metabolic fluxes is a powerful strategy to increase yields of bioactive plant-derived products in heterologous hosts.
An overview of the importance of plant natural products as pharmaceuticals as well as a description of the development of recombinant DNA technology and genetic modification of plants directed toward manipulation of the biosynthesis of bioactive plant natural products is presented.
The other is a database on the target specificity of bioactive plant compounds.
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