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Successful applications of bioactive glass composites will benefit from the attractive properties of bioactive glasses (bioactivity, mechanical strength, stimulation of gene expression) while avoiding the disadvantages (brittleness; difficulties of forming into anatomically relevant shapes).
In this work, a novel mathematical model is proposed to numerically analyze the dissolution and bioactivity of bioactive glasses in relevant conditions for their in vitro and in vivo applications.
It was once reported that crystallization of bioactive glasses, which is necessary to achieve mechanical strength, decreased the level of bioactivity (Filho et al. [1996]), even turning a bioactive glass into an inert material (Li et al. [1992]).
This antagonism between bioactivity and mechanical strength was considered to hamper the application of bioactive glasses.
Mesoporosity is a prerequisite for the versatility of bioactive glasses.
The controllable biodegradability of bioactive glasses makes them advantageous over HA and related CaP.
Therefore, angiogenesis is considered as one of the most important properties of bioactive glasses.
Synthesis of bioactive glasses using the sol gel method has advantages compared to the melting method.
Moreover, the reported effects of Ag-doping on the properties of bioactive glasses are discussed.
The potential application of bioactive glasses for wound healing has been reviewed by Naseri et al. (2017).
Despite these interesting and useful properties, the use of bioactive glasses is restricted due to their brittleness.
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