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If a specific factor in food is suspected of being essential for the growth of an organism (either by growth failure or some other clinical symptoms that are alleviated by adding a specific food to the diet) a systematic series of procedures is used to characterize the factor.
While antimicrobial targets are harder to identify due to the requirement of being essential for growth, potential vaccine targets are easier to identify.
Previous work (Deutschbauer et al. 2005) showed that HI genes have a higher likelihood of being essential than other genes.
In our phase locked networks, we also observed a positive correlation between the network degree k i of a gene and its likelihood of being essential.
Jordan et al. speculate that the reduction in evolutionary rate of the most highly connected proteins could be due to their greater likelihood of being essential for viability of the cell [ 1, 12].
Although the numerical weighting cannot give an exact probability of essentiality for each uncharacterized gene, the weightings should give an estimation of the relative likelihood of being essential for any two genes being considered as candidate targets.
Similar(53)
Of course, freedom of press is essential for democracy.
A good set of lights is essential.
Those kinds of procedures are essential.
A depth of expertise is essential.
Long periods of sunshine are essential.
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