Your English writing platform
Discover LudwigSuggestions(1)
Exact(2)
Blitzing out of base formations puts a lot of pressure on your cornerbacks.
This is because, with the Niners being a run-oriented team and Smith needing vanilla defensive looks, much of San Francisco's passing game takes place out of base formations (two backs, two tight ends – run personnel type sets).
Similar(58)
In actuality, the Falcons are aggressive in a lot of their zone blitz concepts – they just execute those blitzes out of more base formations instead of amoeba looks.
For one, they probably won't get as much consistency out of their tight end this season, which could compromise the integrity of the base formations.
In summary, the most striking feature of this model of Schiff base formation concerns the interplay of residues on either side of the substrate in promoting Schiff base formation.
With the objective of clarifying the mechanism of Schiff base formation, we characterized the binding of quinate and shikimate to the wild-type and K170M mutant DHQD using ITC, NMR, and X-ray crystallography.
Complicating the analysis of DHQD Schiff base formation is the question of whether binding of substrate to the K170M mutant accurately reflects the wild-type Michaelis state.
To address the mechanism of Schiff base formation, we determined structures of the Salmonella enterica wild-type DHQD in complex with the substrate analogue quinate and the product analogue shikimate.
As the functional implications of this presumably nonproductive binding mode have been thoroughly discussed in a recent publication and do not pertain to the mechanism of Schiff base formation, we will leave discussion of quinate complex protomer B here.
Despite the fact that the lipid aldehyde BY-POVPE is firmly bound to LDL and albumin, it is released from these carriers to the phospholipids and proteins of the cell plasma membrane suggesting high reversibility of Schiff base formation.
A comparison to related enzymes suggests that this form of substrate conformational change likely represents a common feature of Schiff base formation in enzymes acting on linear ketone substrates.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com