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The nature of autoregulation dysfunction in these conditions is unclear.
Under normal conditions, the brain maintains a high degree of autoregulation [8].
Any value less than that or reduction of the velocity denoted a global failure of autoregulation.
Within the ischemic core there is a failure of autoregulation, and CBV is ominously decreased in this region.
We defined stage 1 as a decreased CBF or increased CBV as both are signs of autoregulation.
Several factors have been shown to be involved, such as endothelial dysfunction, loss of autoregulation, and a hypovolemic component leading to a decrease in CBF [14 16].
Examples where recent progress has been made include aspects of autoregulation, signal integration in branched pathways, cross-talk suppression, and cross-regulation via connector proteins.
Acute severe hypertension with transient loss of autoregulation system (sympathetic innervations) and subsequent vasogenic edema [7, 11] seems the cause of PRES in our patient.
In ischemic stroke, a failure of autoregulation is assumed, leading to current treatment guidelines of permissive hypertension in the hyperacute phase [2].
As extracts used in the experiment were enriched with simocyclinones, these might indicate the existence of autoregulation by binding most likely simocyclinone or its intermediates.
Even with a stable renal blood flow within the range of autoregulation, the cortical and medulla have different responses to changes in renal perfusion pressure (RPP).
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