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Evidence was based mainly on statistical association of chromatin marks with expression levels of associated genes.
Otx2 drives enhancer activation through affecting chromatin marks and the activity of associated genes.
Also, given the hypothesis of overlap in genetic risk between the two disorders21 we wished to determine if there is overlap in the identity of associated genes.
Such binding inhibits the expression of associated genes — including those that promote stem-cell differentiation into cells of the 'endodermal' lineage.
We excluded disease genes associated with nutritional and metabolic diseases from both panels owing to the large number of associated genes.
These changes were accompanied by a decrease in somatic heterochromatin domains, increased binding of Sox2 to pluripotency-specific targets and activation of associated genes.
Monocyte- and DC-specific enhancers were gradually established at progenitor stages before the expression of associated genes.
Enhancers are cis-regulatory regions in the DNA that not only augment the transcription of associated genes but also play a key role in cell-type specific gene expression1,2.
To study the roles of leptin on tube formation (as a measure of cellular angiogenesis) and expression of associated genes in first-trimester human extravillous trophoblast cells.
Among mutations exclusively detected in post-treatment samples, there were 3 truncating mutations and 17 missense mutations predicated to impact the functions of associated genes by PolyPhen-221 and 9 genes were previously reported to be associated with chemoresistance in several types of cancer (Supplementary Data 7).
The number on top of each bar means the number of associated genes.
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