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The data presented here emphasizes the benefit of a trial design with a less heterogenous population of younger SMA subjects, particularly in light of significantly increased fat mass and lack of apparent benefit of VPA treatment in older non-ambulatory subjects.
Randomized clinical trials (RCTs) that stop earlier than planned because of apparent benefit often receive great attention and affect clinical practice.
Inability to identify appropriate populations for study on the basis of clinical criteria alone may partly account for the lack of apparent benefit.
Because the decision to stop is typically driven by highly significant p value thresholds, trials stopped early because of apparent benefit frequently show large treatment effects.
It seems unlikely that this difference in duration of follow-up (which is determined by the date the sample was collected) could explain a lack of apparent benefit.
If GPs had inadvertently 'compensated' for patients being allocated to the control group by providing a greater level of advice to these individuals, this could also go some way towards explaining the lack of apparent benefit of the nursing intervention.
Similar(52)
Given the uncertainty about the effect of incretins on important outcomes, including pancreatitis, the lack of apparent benefits in glucose control over other drugs, and the relatively high costs, the use of incretins might not be preferable to other available antidiabetic drugs.
In view of the apparent benefit of using other microarray data to corroborate and refine gene lists, we also evaluated the differential expression patterns of the 52 putative photorespiration genes across the 40 microarray data sets described above (Figure 6C; Table S11).
Twenty-five per cent of all Medicare spending is for the five per cent of patients who are in their final year of life, and most of that money goes for care in their last couple of months which is of little apparent benefit.
These interactions can be mutualistic or antagonistic in nature, or in the case of commensal fungi are of no apparent benefit or detriment to the host.
Despite the original verdict, doubts persisted about payouts of many millions that were of no apparent benefit to the company.Although Mr Ackermann has always insisted that his legal difficulties have not detracted from his role running Deutsche, he may now conclude that he cannot continue as boss of a very large, increasingly complex institution while another long court case grinds on.
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