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We retrieved the complete articles of all preselected references.
The QTL mapping was conducted by a two-step procedure: in a first step an entire genome scanning is performed to draw the LOD curves and identify the peaks where the putative QTL are located, in this preliminary fit are estimated the additive effects of all preselected cofactors.
The complete articles of all preselected references were retrieved and analyzed by two different researchers, and later included or excluded according to the criteria reported previously.
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First, imputation model was constructed for the overall score using linear regression (pmm method) and another for multiple imputation of the hDS status using a logistic regression model (logreg method) with all preselected risk factors of DS.
To confine the scope of a metagenomics screen, ecological enhancement can be very useful as it decreases library complexity by an increase of the prevalence of genes of preselected and dominating target microbes.
Knockout mice are created to examine the function of a preselected gene.
IBD-GS was also unbiased when all members of preselected favorable families were genotyped (IBDall).
This 'thermodynamic' model for expression of gene regulation is conceptually related to our approach, but the emphasis on spatial prediction and the analysis of promoter regions of preselected genes make it difficult to compare.
As mentioned earlier, the ability of pluripotent cells to grow in vitro for a prolonged time allowed the introduction of genes into the genome (gain-of-function) or the inactivation of preselected genes by gene targeting via homologous recombination (loss-of-function).
However, methodological differences such as a high rate of depression and WMH in the naMCI group, use of SPECT instead of PET, and the analysis of preselected ROIs disallow an easy comparison between the results presented in the present study and those published previously.
Moreover, all the studies either determined the expression of preselected genes such as TLRs, MHC-II molecules, chemokines and cytokines by quantitative RT-PCR or used the Affymetrix microarray, so the measurements were limited to the level of transcription.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com