This calls into question the present approach to antibiotic dosing in these patients and supports use of more aggressive dosing strategies to minimize the likelihood of clinical failure.
More aggressive dosing of all of the agents characterized could preserve their clinical utility, but this must be balanced with safety and tolerability issues by the physician.
Among the modeled agents, only imipenem remains a viable therapeutic option against this organism; more aggressive dosing of the other compounds does not bring current effectiveness within range of earlier clinical reliability, suggesting that an impact on outcomes may be observed.
Genetics Institute applied a "more aggressive" dosing regimen: consecutive intravenous daily injections of IL-12.
Against P. aeruginosa, cefepime 2 g q8h remains a potent choice for therapy; the therapeutic utility of imipenem and piperacillin-tazobactam can be maximized by aggressive dosing.
At a dose of 10 mg/kg or higher, signs of toxicity were evident in infected animals (weight loss, lethargy), precluding more aggressive dosing regimens.
Anyone who does not advocate yet more aggressive doses of neo-liberalism – more privatisation, more cuts to the taxes of the wealthy, more attacks on workers' rights – is liable to come under suspicion, too.
He thinks that by giving "aggressive" doses of OSI's drug, and by testing it both as a single agent and with chemotherapy, he and his colleagues stand a very good chance of getting Tarceva approved.
To determine if these enhanced T cell responses translated to functional immunity, we challenged immunized mice with an aggressive dose of 1 × 10 B16 tumor cells expressing OVA.
Monitoring of trough serum vancomycin concentrations is recommended for patients receiving aggressive dose targeting, for patients with unstable renal function, and for patients receiving concurrent treatment with nephrotoxic agents.
