Part of the current treatment for sepsis is aimed at safeguarding or restoring oxygen supply to tissue cells by early aggressive administration of intravenous fluids, and the use of inotropic and vasoactive agents.
They compared immediate and delayed fluid resuscitation and reported that aggressive administration of intravenous fluids should be delayed until the time of operative intervention.
This therapy included the aggressive administration of fluids, vasopressors, red blood cell transfusion and treatment with inotropes.
Early and aggressive administration of plasma may result in diluting the blood cells with a decrease in hemoglobin level [ 20].
However, this benefit may rely at least in part on the aggressive administration of prehospital interventions by the air medical team, countering previous research suggesting prehospital intervention for trauma has no mortality benefit [ 47].
The impact of aggressive and prolonged volume administration on hepatosplanchnic oxygenation and mitochondrial function in human sepsis should be determined.
Determination of the monoclonality of the deposited immunoglobulin is vital to make the correct diagnosis and enable an early administration of aggressive immunosuppressive therapy.
Another often accepted but poorly defined risk is the contribution of electrolyte disturbance during acute administration of aggressive loop diuretic therapy with AHFS admissions.
The administration of aggressive diuretic therapies has generated concerns about renal safety, and some controversial results have been published in recent years [ 27, 28].
Despite the administration of aggressive treatments, the prognosis is poor, with the median overall survival (OS) ranging from 8 to 16 weeks [ 1, 2].
From across Latin America, calls for hemispheric unity in the face of an aggressive US administration are growing louder; Bolivian president Evo Morales recently suggested that "our Mexican brothers should look more to the south".
