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These studies were systematically reviewed by Moore et al 20 and of the studies considered only one 21 was found to be of adequate trial design to be informative regarding the potential efficacy of cell therapy and this trial was negative.
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Drug resistant epilepsy is currently defined as the failure of adequate trials of 2 tolerated and appropriately chosen and tried antiepileptic drug (AED) schedules (whether as monotherapies or in combination) in order to achieve sustained freedom from seizures [ 1].
Factors related to delay in starting of clozapine included higher age, longer duration of illness, age more than 20 years of age, polypharmacy, use of an adequate trial of typical antipsychotic medication, patients from urban locality and those with onset of illness prior to introduction of clozapine into Indian market.
Background: The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptic drugs is a major challenge.
The most important reasons for failing entry into a study remain lack of an adequate trial and unmet inclusion criteria.
Our study included subjects who had severe CRS (mostly white and black Americans from an urban, academic center) who failed to respond to adequate trials of medical therapy.
All subjects had previously failed to respond to adequate trials of conservative medical therapy including antibiotics, oral or intranasal steroids, and leukotriene modifiers, and were scheduled for endoscopic sinus surgery.
Two things are notably lacking: an acknowledgement of the problems of funding adequate trials and a discussion of the equivalent risks and inadequacies of conventional medicine.
No SAEs were reported.> The objective of the study was to compare sertraline with continued CBT for the treatment of pediatric OCD among a sample of children who had received an adequate trial of CBT (14 weeks of individual outpatient exposure-based CBT) and deemed to be CBT non-responders (CY-BOCS ≥16).
Finally, patients were allowed to crossover (32 out of 131 who had an adequate trial of therapy), making analysis even more difficult.
Table 1 Refractory chronic migraine criteria (proposed) [3] 1. Patient has diagnosis of chronic migraine (or migraine) 2. Patient has failed adequate trial of at least two out of four drug classes a.
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