Sentence examples for of additional driver from inspiring English sources
The study of β-cells could also benefit from the development of additional driver mice in which a single copy of Cre fused to one or even two ERT2 domains is inserted downstream of a β-cell specific promoter, such as insulin, using BAC-based recombination technologies.
We conducted further sensitivity analyses by varying accumulation rates u of additional driver mutations.
The effects of additional driver mutations depend on the driver mutation rate.
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This is supported by additional numerical experiments where we vary the maximal number of additional driver mutations N: the inflection point σ ≈ 2 s disappears when N = 0.
This model may be utilized to test the contribution of additional driver alterations in SCC, as well as for preclinical drug discovery.
Identification of additional drivers of ARC in septic patients is not possible with the current dataset, although this is likely to reflect the interaction between the innate inflammatory response and available organ reserve.
Taken together, the two lines of evidence both natural and experimental perturbations indicated that Klf7 is a key driver mediating the effects of additional drivers in groups I and II, which in turn affect morphine response diversity.
The inflection point at σ ≈ 2 s in Figure 2A is due to the accumulation of additional drivers within tumours and associated increases in the likelihood that the tumour eventually resists treatment.
Our model predicts that the strength of selection for additional driver mutations determines whether or not a cancer is likely to evolve a mutator phenotype and suggests that future efforts should be devoted to measuring the degree of fitness effects of mutations in carcinogenesis.
In the case of strong selection for additional driver mutations, the growth of the most aggressive clone (the clone with the most driver mutations) is very rapid, so that many cells that are 'susceptible' to acquiring the next driver mutation are rapidly produced.
