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Equilibrium simulations of a WW protein domain captured multiple folding and unfolding events that consistently follow a well-defined folding pathway; separate simulations of the protein's constituent substructures shed light on possible determinants of this pathway.
Taken together, they provide initial evidence on the feasibility of a WW approach to CE3b cysts in selected circumstances.
By this reckoning, dystrophin shares one character uniquely with dystrotelin (the position of the E7/E8 boundary) and one with dystrobrevin (the fusion of E5 and E6), while dystrotelin and dystrobrevin share the absence of a WW domain.
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The structure determined by the authors shows that the docking of the substrate to a WW domain attached to the HECT domain places steric constraints on the distance of the ubiquitylated lysine from the WW docking site.
The operation of a WW-6 spiral for the concentration of an iron oxide ore is analyzed through the size recovery or partition curves of the minerals.
There are lots of different ways a WW scattering can occur, and in the Standard Model, some of them involve the exchange of a Higgs boson.
For the MRI atlas, constant window settings were used: T2w images with a window width (WW) of 400 and a window level (WL) of 170, and pre-contrast and post-contrast T1w images with a WW of 250, a WL of 100 and a WW of 350 and a WL of 150, respectively.
This is in marked contrast to the behaviour of a multiple WW-domain construct (WW domains 2, 3, and 4) from Nedd4 binding to the βENaC PY motif peptide less strongly (KD = 65 µM) than WW3 alone (KD = 11.1 µM) as we reported previously [15].
Other than p300, the most well-defined transcriptional co-activator of p73 is YAP; a WW domain protein that has strong transactivation activity but lacks a DNA-binding domain.
Nonetheless the WW domain interaction site is essential, though due to the presence of a second WW domain interaction site that can also mediate interactions through dystroglycan, is partially redundant [ 42].
Over one lunch, he'd told me that a friend of his, the author William Manchester, had recently discovered that a fragment of a Japanese WW II bullet was still lodged near his heart, setting off airport metal detectors.
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