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Overexpression of a truncated form of yeast HMGR lacking the regulatory domain (tHMGR) results in increased flux towards end products22.
In addition, expression of a truncated form of CED-7 lacking its C-terminal region was able to suppress the ced-3 defect in axonal regeneration.
Overexpression of a truncated form of CAMGAP1 interferes with the internalization of transferrin receptors, suggesting that CAMGAP1 may play a role in clathrin-mediated endocytosis.
We also found that expression of a truncated form of CED-7 lacking its C-terminal region CED-7ΔC CED-7ΔC 6a) Figm the unc-25 promoter was able to suppress the ced-3 defect in axon regeneration, whereas expression of the wild-type CED-7 was not (Fig. 6a and Supplementary Table 1).
The crystal structure of a truncated form of EpsE in nucleotide-liganded and unliganded state has been determined, and reveals a two-domain architecture with the four characteristic sequence "boxes" of the GspE subfamily clustering around the nucleotide-binding site of the C-domain.
Combining this approach together with the overexpression of a truncated form of 3-hydroxyl-3-methyl-glutaryl-CoA reductase (HMGR) and deletion of lipid phosphate phosphatase encoded by LPP1 led to a strain with a productivity of 0.18 mg/gDCW h.
In addition, inhibition of ras-Raf interactions by expression of a truncated form of Raf containing only the ras binding domain blocked VEGF-stimulated MAPK activation.
As mentioned above, the published structure of CifEc is of a truncated form, lacking the first 99 amino acids.
The crystal structure of a truncated form of EPEC Cif (lacking the first 99 amino acids) was recently determined.
To explore the mechanisms at play in the oocytes, we generated a YFP fusion of a truncated form of hTPX2 lacking the 118 first amino acids.
The crystal structure of a truncated form of CifEc (lacking the N-terminal 99 amino acids) has recently been published [13].
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