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People of my acquaintance in the medical profession assure me that, unlikely as it sounds, one can indeed die of a toxicity caused by both type and number of plaids, their juxtaposition on the skin, and other factors.
The inclusion of a toxicity control, e.g. glucose of acetate, can help to distinguish between non-degradability cased by persistence or by toxic inhibition.
Our approach is based on minimization of a toxicity cost function, a mathematical model that allows calculation of the cumulative cytotoxicity during a candidate CPA addition or removal procedure using predictions of cell membrane transport.
Previously, we reported a new strategy for mathematical optimization of CPA addition and removal procedures which involves minimization of a toxicity cost function while constraining cell volumes within osmotic tolerance limits.
The current work reports on the preliminary results of a toxicity test using screening experiments to check the efficiency of an innovative passive treatment plant designed for acid mine drainage purification.
Secondly, the toxicity data for the single substances can be deemed rather conservative, as (i) exact values were used in case of censored data (e.g. 100 mg/l in case of EC50 > 100 mg/l), (ii) the lowest value was used in case of a toxicity range (e.g. 1 mg/l in case of EC50 between 1 and 10 mg/l), (iii) NOEC or EC10 was used if EC50 was not available, and (iv) toxicity estimates for the a.s.s
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However, there were too few pairs to draw conclusions about the statistical significance of a toxicity-reducing effect.
By using xenografted embryos, the value of co-administration of a toxicity-mitigating agent can be studied in the context of ongoing primary drug efficacy.
In this perspective, we performed a toxicity study of PtNPs.
The release of hemoglobin from the erythrocytes (RBC) was used as a measure of toxicity of these copolymers.
The LD50 is used as a general indicator of acute toxicity of a substance.
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