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The lack of a time dependency may suggest that the reaction has progressed to completion within the initial 20 min and the GRG is only being distributed through the GIT beyond this.
Time-specific correlation coefficients were 0.26 0.28 for A1C with fasting/preprandial and 0.22 0.30 for A1C with postprandial glucose, without evidence of a time dependency.
The existence of a time dependency of substitution rates appears to now be well accepted [e.g. [ 56]] although its magnitude continues to be debated [ 57, 58].
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Animal studies have shown an upregulation of proinflammatory genes already very soon (hours to days) after the induction of retinal detachment together with a time dependency of certain cytokines [16], [17].
These results may indicate a time dependency of this inhibitor's ability on reducing endogenous H2S production that contributes to increase in arterial pressure.
In the duplication-divergence model, on the other hand, one would not expect a time dependency of exon numbers, since this mechanism should work the same at every time horizon.
The above-mentioned point (b) poses a technical challenge, because the real-time dependence of age on the epidemiology of influenza introduces a time-dependency in its influence on the readings of the infrared thermoscanners (i.e. a simple statistical adjustment does not hold in such instances).
In fact, a time-dependency of the molecular clock rates has been recently proposed and discussed [ 24, 25].
In line with our findings, van Kaam and colleagues have shown a dose-dependency of the surfactant effect whereas a time-dependency with declining effects over time could be shown in the present study [ 36].
From the previous results in this study which highlighted a time-dependency of the telomerase enzyme, MCF10A cells were treated with the compounds for 5 days and then analyzed.
This accumulation ratio was as expected for the terminal half-life (t1/2) of this compound and demonstrates an absence of time dependency in the PK of AZD9773.
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