To ensure that the stage-dependent decrease of survivin-2B expression was not the result of a stage-dependent increase of GAPDH transcripts used as an external standard, we additionally calculated the ratios of mRNA levels between survivin-ΔEx3 or survivin-2B on one hand and survivin as an internal standard on the other hand.
Therefore during organogenesis, BMP antagonists can produce a spectrum of phenotypes in a stage-dependent manner by adjusting the level of BMP activity.
Previous studies indicated that changes in muscle environment influence the ability of HDACi to promote regeneration, with a stage-dependent effect of HDACi on skeletal myogenesis in vitro and in vivo (Iezzi et al, 2002, 2004).
Since the major impacts of foxo overexpression in the CCAP/bursicon neurons were observed during metamorphosis (and not in larvae), we wondered whether altered InR function would also affect growth of these neurons in a stage-dependent manner.
Although accumulating evidence indicate that expression of Cav-1 is altered in a stage-dependent manner during progression of various types of cancers [1], [2], [3], [4], the precise roles of Cav-1 in cancer development, progression, and treatment remain to be fully defined.
Consistent with these observations, we have recently found that markers of neurogenesis are reduced in a stage-dependent manner in the hippocampus of patients with AD.
Self-renewal and cell fate choice of NPC are coordinately controlled in a stage-dependent manner, but the mechanisms underlying such coordination remain poorly understood.
With spread of disease other functions are also affected and a stage-dependent pattern of deficits unfolds [ 9].
Since this subpopulation of interneurons are born during later stages of embryogenesis (Valcanis and Tan 2003), our findings also suggest a stage-dependent requirement of Lhx6 activity.
Since we did not observe any modulation of atherosclerosis at both sites a stage-dependent effect is unlikely.
Immunocytological investigations revealed a stage-dependent sensitivity of thoracic GABAergic motoneurons to 3g-conditions concerning their soma sizes but not their topographical arrangement.
