Further, we show that the orientation biases are IS-family specific and not the result of selection for a specific orientation.
The lines from different planes of atoms form Kikuchi patterns which can be related to crystal structures without need for a specific orientation of the crystals.
Thus, it is possible that with a β-augmentation mechanism, SurA binds to only one type (e.g., odd-even) of hairpin in a specific orientation, based on the properties of the substrate, such as its connection loop and hydrophobic surface (e.g., the Ar-X-Ar motif), as well as the peptide direction.
We observed that the conserved CTCF binding sites that are enriched at the edges of conserved domains have a specific orientation of their motif relative to chromosomal domains.
This change might affect the 3D conformation of nifedipine or indicate that a specific orientation of the nitro group is required for activity.
An active catalytic core for XBP1/HAC1 mRNA cleavage is unlikely to consist of all subunits within the IRE1 oligomer, but rather, oligomerization will lead to formation of the catalytically active pocket by establishing a specific orientation of catalytic residues.
By determining the Lys preference in Rps5-substrates, as well as by alanine scanning of most of the HECT-domain, they first provide convincing evidence that a specific orientation of N- and C-lobe, and the substrate-binding WW-domain of Rsp5 is important for ubiquitin transfer to the substrate.
The analysis of a number of microarray datasets assured us that the composite elements with a specific orientation of AuxRE and the coupling motifs and the certain range of spacer length between them were associated with auxin responsiveness.
Inclusion is fundamental: the young, women, seniors, and vulnerable people (with health or financial issues) must be included in the labor market and must participate in the creation of the future, with a specific orientation towards general wellbeing, at both the individual and the community levels.
