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Through a meta-analysis of studies retrieved from PubMed, EMBASE, the Cochrane Library, and the Google Network between January 1996 and June 2013, the authors found a moderate accuracy of a SAA test in the diagnosis of neonatal sepsis, suggesting that SAA might be promising for the diagnosis of neonatal sepsis.
Clinical presentation of a SAA is variable, with most patients being asymptomatic and detected incidentally [4].
The hybrid SAA integrates the basic structure of a SAA together with features borrowed from the fields of genetic algorithms (GAs) and local search techniques.
They tuned the filters for maximum SNR improvement and analyzed the performance of a SAA in terms of both sensitivity and specificity.
Not only they did optimize and test their method in terms of how filtering improved the SNR, but also they were the first to report the sensitivity of a SAA after filtering.
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Contrary to all mammalian species studied, the rat lacks expression of A-SAA proteins [15].
Stratified analyses showed that the variability of A-SAA levels was higher in older subjects.
Furthermore, the association of A-SAA with incident type 2 diabetes was only significant in younger subjects.
This suggests that elevated levels of A-SAA could be associated with early alterations in glucose control.
In the current study, the association between levels of A-SAA and incident type 2 diabetes seemed to be age dependent.
The relevance of high circulating levels of A-SAA in the pathogenesis of type 2 diabetes may be modulated by age.
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