Different versions of a receptor (encoded by genes that have slightly different DNA sequences) can be more or less sensitive to the appropriate hormone.
One cannot directly compare the results of a receptor agonist such as a triptan with that of a receptor antagonist such as the CGRP antagonists, olcegepant and telcagepant.
Finally, the structure of a receptor is connected to cholesterol [174 176].
A shape matching method was employed to place a ligand in the binding site of a receptor.
High expression for the Nt_BRIL construct of a receptor did not always correspond to high expression for the ICL3_BRIL construct.
A ligand is a small molecule bind to several residues of a receptor.
The very notion of a "receptor," seen so often in cell biology, suggests this schema.
As the rodents get older, cells in their liver sport less of a receptor called LAMP-2A.
Of note, studies with other receptors show that antagonists for one signalling pathway of a receptor may be agonists for another pathway.
Our results show some key aspects for the choice of the method and pinpoint pitfalls in the selection of a receptor template.
The approach also directs future efforts to refine the assessments by identifying which chemicals make significant contributions to combined exposures of a receptor.
