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This study was of a nested case control design.
Operationally, the implementation of a nested case control study in real time with the CAPRISA 004 trial was successful and resulted in minimal disruption of clinical trial procedures.
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Participants still followed at T8, without dementia before this date and with an accurate date of diagnosis of dementia, were eligible for a nested case-control analysis in the PAQUID cohort.
Participants represented a random study sample of potential control subjects for a nested case-control genome-wide association study of type 2 diabetes in the population.
NHS participants in the replication phase of this study were selected for a nested case-control study of telomere length and skin cancer risk from the blood subcohort [97].
Study Design: With the use of a nested case-control design from an original cohort study of 2929 women, results of tests from 50 women with a spontaneous preterm birth at <32 weeks and 127 women with a spontaneous preterm birth at <35 weeks were compared with results from matched-term control subjects.
These data were collected as part of a nested case-control study.
Primary hypothesis 2 will be addressed through the use of a nested case-control study from participants within the cohort.
With the use of a nested case-control design, a large cohort of NSAID users was followed for 26 months.
Our results differ from those of a nested case-control study [ 15] that reported increased risk of IP with greater consumption of protein and red meat.
We previously reported an association between 25(OH D concentrations and incident diabetes on the basis of a nested case-control design by using blood samples from the 1993 1997 baseline survey taken 4 y before the current study (8).
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