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This simple nanoDDS formulation allows high loading of clinically used chemotherapeutics such as DOX and behaves as a targeted nanoformula by specific delivery to CD44 receptor expressing tumor cells of a high payload of drugs.
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Similar to aforementioned studies, the liposomes were of a bimodal nature containing a high payload of Gd-containing lipid for MR imaging and fluorescent lipids for fluorescent imaging, which enabled extensive evaluation and validation of the applied strategy.
To improve the chemotherapeutic efficacy, new designs of UCNPs-based therapeutic agents are important, which have a high payload of drugs and enable targeted release of therapeutic drugs.
The hollow cavity within a HGNP is able to accommodate a high payload of chemotherapeutic agents.
So the EPR effect coupled with active targeting with nanovectors can achieve a high payload of drug within the tumor tissue.
From a molecular MRI perspective, such nanoparticle agents are able to deliver a high payload of Gd-chelates to the target site and therefore amplify signal.
MPIO provide excellent contrast effect for magnetic resonance imaging, through delivering a high payload of iron oxide [ 15].
Moreover, the endothelial cells are directly accessible from the bloodstream, enabling nanocarriers with a high payload of angiostatic drugs to reach their target site efficiently.
For example, a high payload of doxorubicin was coated and successfully released from both the outer and inner shells of polyethylene glycol (PEG) hollow gold nanoparticles.
When equipped with a high payload of contrast generating material and conjugated with one or more types of targeting ligands, liposomes turn into a potent contrast agent for tumor angiogenesis imaging.
As a bimodal contrast agent, the above-described liposomes were used, which have a high payload of Gd-containing lipid for MRI purposes and rhodamine fluorescent lipids for optical imaging.
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