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The type A and type B structures of a given aggregation number can, moreover, inter-convert, with the effective nucleation of a type B species occurring via the conversion of a type A to a type B species.
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We describe rationality assumptions as integrity constraints using a simple propositional language and we explore the question of whether or not a given aggregation procedure will lift a given integrity constraint from the individual to the collective level, i.e., whether the collective choice will be rational whenever all individual choices are.
As discussed in the previous sections, the electron density analysis offers many tools to investigate materials, in particular the stereo-electronic features that enable understanding the robustness of a given type of aggregation or the breakdown of a crystal property in terms of atoms, functional groups or molecular building blocks.
Such metrics are also needed if end users are to be able to understand the performance of a given system, or an aggregation of systems.
There was no correlation between aggregation of a given protein and arsenite-sensitivity of the corresponding gene deletion mutant (Fig. 5D).
In our experience, PEG purification by itself does not enhance (and also does not reduce) the tendency for aggregation of a given object at a given solution condition (see Figure 1).
However, it is still challenging to assess the aggregation risk of a given biotherapeutic in the absence of a reference protein of similar nature for which experimental aggregation properties are known.
We demonstrate the existence of a striking negative correlation between the aggregation propensity of a given variant and the oxidative stress it elicits.
The key idea is very simple: first define a set of "elementary" chargeable resources and then describe the overall resource consumption of a given resource/service in terms of an aggregation of the consumption of these elementary resources.
The aggregation behavior of a given polypeptide is strongly influenced by the intrinsic properties encoded in its sequence.
While it is easily recognized that many factors can come into play in determining the aggregation propensity of a given protein or peptide system, in practice the most commonly used strategy in protein design is to incorporate a certain number of charged residues to prevent or alleviate aggregation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com