The image of a cluster consisting of a differentiated and differentiating cells showed that the deposition of secondary cell walls precedes the vacuole rupture (Fig. 4H).
They may be important for the differentiation process or for expression of a differentiated phenotype.
We sought to address the impact of telomere dysfunction not only upon the capacity for cell differentiation but also upon the maintenance of a differentiated state.
This process can be regarded as differentiation, as pericytes have stem cell features, or transdifferentiation of a differentiated cell toward a different phenotype, and this is clearly a matter of debate.
Cumulatively, these data indicate that S14 itself is not sufficient to promote a differentiation program in mammary tumors; rather, S14 may support the proliferation or survival of a differentiated mammary tumor cell type.
Considering the physiologic turnover of mammary epithelial cells during a woman's reproductive life (i.e., cyclical switching between differentiation and involution), this finding seems to suggest the persistence of a differentiated phenotype due to a defect in lobular involution.
For the first time, it was shown that a morphogen may determine the function of a differentiated cell according to its spatial location within a specific tissue, termed "post-differentiation patterning" (Gebhardt and Hovhannisyan 2010).
The unmodified appearance of the surface is consistent with the absence of a differentiated interior.
There are also unknown risks involved with transplanting SCNT-derived stem cells into humans, because the mechanism by which the unfertilized egg is able to reprogram the nuclear DNA of a differentiated cell is not entirely understood.
In animals the best evidence for retention of the entire set of genes comes from whole animal cloning experiments in which the nucleus of a differentiated cell is substituted for the nucleus of a fertilized egg.
Two studies examined the effects of a differentiated model of transformational leadership on follower outcomes.
