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Others accused the prosecutor of being part of a destabilization plan orchestrated by the United States.
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Mutations at Arg1699 R1699WW and R1699Q) significantly reduce peptide binding through loss of contacts to the main chain of the Phe(+3) residue and, in the case of R1699W, to a destabilization of the BRCT fold.
This observation strongly supports the notion that the modification of Aim24 by the HA-tag, like the deletion of Aim24, leads to a destabilization of the MICOS complex.
This increase in constitutive activity of the mutant is due to a destabilization of the inactive conformation of the receptor by breaking the polar interaction.
Together, these data suggest that achieving complete purity of brain-derived αSyn leads to a destabilization of native multimers.
This mutation led to a destabilization of the Notch3 heterodimer and to a constitutive activation of the Notch3 receptor (Fouillade et al., 2008).
The crystal structure of monomeric PS II, albeit available at medium resolution so far, does not give indications of either a destabilization of subunit D1 or a structural reorganization of subunit PsbO.
"We are on our way to a destabilization of the world climate that has advanced much further than most people or their governments realize".
Low pH led to a destabilization of the humic substance conformation.
These modifications may lead to a destabilization of some proteins under the extraction conditions.
We attribute this to a destabilization of the clathrate phase due to increasing free cage space.
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