Phalloidin staining of WT and epsin TKO cells shows a major loss of stress fibers with a corresponding accumulation of elongated F-actin foci (see inset) in TKO cells.
Further, treatments with XAV939, ADP-HPD and XAV939/ADP-HPD combined, resulted in diminution of this high molecular weight pool of DNA-PKcs, as well as a corresponding accumulation of DNA-PKcs degradation products compared to the DMSO treated controls.
In contrast, after 48 h of Dex induction, MCF-7TG cells showed a gradual disappearance of G1-phase cells and a corresponding accumulation of S-phase cells.
Expression of one of these mutants in S. pombe results in reduced incorporation of Rpn10 into proteasomes and a corresponding accumulation of high-molecular-mass polyubiquitin conjugates.
However, the ectopic transcripts were not mirrored by a corresponding accumulation of the protein products of these genes.
In yeast, a reduction in levels of the ribosome biogenesis enzyme Emg1 causes a decrease in 18S rRNA levels with a corresponding accumulation of its immediate precursor in the rRNA processing pathway [7].
Periplasmic d-xylose and d-glucose dehydrogenases use the pyrroloquinoline quinol (PQQ) prosthetic group to transfer electrons to cytochrome c in the respiratory chain, with a corresponding accumulation of d-xylonolactone or d-xylonate in the medium (Galar and Boiardi 1995; Hardy et al. 1993).
All of the patients have a history of smoking, resulting in the presence of tar deposition and corresponding accumulation of tissue macrophages that harbor the ingested tar particles.
A complex regulatory network triggers initiation of seed maturation and corresponding accumulation of storage products.
Loss of P450 activity itself was not responsible for its auto-induction (although the corresponding accumulation of a metabolite produced, e.g. a bile acid precursor, which binds to CYP3A11 could explain the stabilization of this protein).
