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Treatment according to randomization starts as soon as possible after allocation, with a maximum of 2 weeks delay.
Treatment was delayed for 1 week for patients with ⩾grade 1 diarrhoea (maximum of 2 weeks delay).
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A maximum of 3-week delay in treatment was allowed.
Even if previous transarterial chemoembolization (TACE) may improve PVE results [ 16], a minimum of 3-week delay between TACE and PVE is recommended.
PVE is contraindicated in the following types of patients: Tumors invading the portal vein Portal hypertension (blocked to free hepatic vein pressure gradient >12 mmHg) Coagulation disorders (PT < 60%, platelet count <50 G/l) Even if previous transarterial chemoembolization (TACE) may improve PVE results [ 16 ], a minimum of 3-week delay between TACE and PVE is recommended.
Tumors invading the portal vein Portal hypertension (blocked to free hepatic vein pressure gradient >12 mmHg) Portal hypertension (blocked to free hepatic vein pressure gradient >12 mmHg) Coagulation disorders (PT < 60%, platelet count <50 G/l) Even if previous transarterial chemoembolization (TACE) may improve PVE results [ 16 ], a minimum of 3-week delay between TACE and PVE is recommended.
Continuous infusion of AC163794 for 4 weeks delayed the development of diabetes in ob/ob mice.
All patients received the planned dose on time, with the exception of three patients experiencing a 1 4 weeks delay in dosing as a result of their symptomatic deterioration.
Of the periods assessed, a ≥12 weeks delay appeared optimal.
Sixth, the physical status may change during the 3 weeks delay of high altitude exposure.
Limiting toxicity (LT) was defined as grade 3-4 nonhematoxicitytoxicity, grade 4 hematologic toxicity, febrile neutropenia, or any toxicity determining >2 weeks delay of medical treatment.
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