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We have found the proportional odds method to have greater power to detect important risk factor associations than more commonly used binary (yes or no) outcomes (18 ).
The proportional odds method does not necessarily require such a model, but may not have a proper interpretation if effect estimates vary substantially by cut-off (a violation of the proportional odds assumption).
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If the example sites are drawn from a Boltzmann distribution, where sites are sampled in proportion to their affinity, then log-odds methods have similar accuracies.
Using Mantel-Haenszel odds ratio method the OR was 15.1 (CI95% 8 36) with a p value of 0.00000000.
The relative risk (RR) was estimated by the odds ratio method, to determine the correlation between genotype of the CYP2E1 gene and NPC development.
Using a ranking system based on combined an odds ratio method, the authors came up with a set of top ranking genes that future studies may be able to use as a working blueprint.
However, in spite all these practical odds, the method produced results that are in high concordance with the known biological facts (a number of the top ranked TF are either already known diagnostic markers of represent previously proposed markers for diagnosis of OC) and also implies some of the new diagnostic markers for OC.
Additionally, we compiled three other SZGene lists: (1) 270 genes having at least one positive association result in the SchizophreniaGene database (accessed in April 2008) [ 20], (2) 124 genes having at least two positive results in the SchizophreniaGene database, and (3) 75 SZGenes selected by a combined odds ratio method from association studies [ 62].
Sun J. et al. (2008) surveyed the increased association studies from the SchizophreniaGene database in ethnic populations [ 5], in which candidate genes are selected and ranked by the combined odds ratio method as an important index of the candidate genes [ 6].
For each QTL, a support interval (SI) based on the "2-logarithm-of-odds drop" method is reported.
Random effects meta-analysis on log-odds scale (method 8) led to similar results, but with a somewhat smaller asymmetric prediction interval (0.58 to 0.89).
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