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Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system.
These models successfully guided the design of antibodies for the localization of SP-G and SP-H in different human tissues, including lung and ocular system.
In the ocular system, the a3 subunit accumulated in the choriocapillary meshwork in uveal tissues.
We also examined the expression pattern of each isoform of the a subunit in the murine ocular system.
Recently, V-ATPase is shown to be involved in the proper development of the ocular system in flies and fish [19], [20].
To understand the relevance of V-ATPase in the physiology and development of the ocular system, and to better understand the etiology of visual impairment associated with ARO, we examined the ocular defects in the a3 deficient mice.
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In humans, defective microfibril function results in several diseases affecting the skin, cardiovascular, skeletal, and ocular systems.
Finally, we outline the challenges of these MEMS-based ocular systems based on two critical aspects, including material compatibility, and system packaging.
Such a combined approach should address causes of abnormal cervical afferent input as well as the important links between the cervical, vestibular and ocular systems and adaptive changes in the sensorimotor control system.
It also discusses the application of currently available ocular systems to veterinary ophthalmology and recent developments in the field of drug delivery to the human eye and their possible application to veterinary ophthalmology.
The understanding of cell response to biomaterials and structure-function correlations, she said, is being leveraged to design composite biomaterials that can direct tissue repair and regeneration for translational tissue engineering in the musculoskeletal, craniofacial and ocular systems.
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