All except the ocular form have been associated with patients who have underlying hematological diseases [ 2, 3, 5].
Four (44.4%) of those children developed an asymptomatic form of the disease, three (33.3%) had asymptomatic meningitis, one (11.1%) developed the systemic form of toxoplasmosis, and one (11.1%) had an ocular form of toxoplasmosis.
One of these children had the systemic form (his mother was diagnosed with acute toxoplasmosis earlier in pregnancy), and another child was born with the ocular form of the disease (the mother had acute toxoplasmosis 3 months before pregnancy).
Most treatments for diabetic eye conditions rely on systemic (oral) or intravitreal administration, and there is still a demand of efficient and comfortable ocular dosage forms.
Over- the-counter (OTC) products are examples where one or more excipients are used as atypical active pharmaceutical ingredients in oral, topical, parenteral and ocular dosage forms (Boddu et al. 2015).
In recent decades, scientists has extensively studied about ocular dosage forms which have recorded the toxicological signs of ocular tissues exposed to topically applied drugs.
The results proved the importance of the presence of the thiol groups and suggested that a ThioPASP formulation can be useful as an in situ gelling, ocular dosage form.
A further approach was the implementation of the mucoadhesive concept to optimize the ocular dosage form.
This category is further divided into 2 subtypes: the highly aggressive, often fatal rhino-ocular-cerebral form and the less fatal rhino-maxillary form.
The patients whose sera were tested represent, with the exception of ocular melanoma, all forms of melanoma.
