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During mammalian ocular development, several signaling pathways control the spatiotemporal highly defined realization of the three-dimensional eye architecture.
Our aim was to utilize publicly available and proprietary sources to discover candidate genes important for ocular development.
The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development.
The advent of high throughput next generation sequencing (NGS) has accelerated the pace of discovery of disease-associated genetic variants and genomewide profiling of expressed sequences and epigenetic marks, thereby permitting systems-based analyses of ocular development and disease.
Here, we show that the soluble heparan sulfate level in murine intraocular fluid is high particularly during ocular development.
As previously documented [50] and confirmed in the current report, whether or not a mouse either fails to express FasL, or over expresses membrane-bound FasL, does not appear to affect ocular development or normal lymphocyte homeostasis.
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We previously showed that the different flashing lights could result in distinct effects on the ocular growth and development of myopia.
These data indicated that both TGF and CCN2 were coexpressed in sclera tissues in flashing light-induced myopia model, suggesting that TGF- β-CCN2 signaling might play an important role in the ocular growth and development of myopia.
This group of children, particularly those with macular haemorrhages detected during the ocular examination, as in figure 2, requires a long-term observational study in order to understand the significance, if any, of retinal haemorrhages on future ocular growth and development.
We propose that macular development and ocular maturation involve 2 distinct processes: (1) retinal stretch (transverse growth) and (2) anterior-posterior (AP) retinal layer growth.
CCN2 signaling pathway might play a significant role in flashing light-induced ocular growth and myopic development.
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