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There is disagreement on whether commonly occurring exposures in welding, ferroalloy, and other industrial processes produce neurologically significant neurobehavioral changes representing parkinsonism.
Since worms displayed DA neurodegeneration in response to a purified proteasome inhibitor, we considered possible sources of naturally occurring exposures.
The regression tree will have limited power to identify whether rarely occurring exposures are harmful.
In studies that require lifelong exposures, it may be necessary to make informed estimates for previously occurring exposures.
Some radiation-induced cancers attributable to naturally occurring exposures, such as cosmic and terrestrial radiation, are not preventable.
Statistical techniques such as factor analysis and latent class analysis will be used to create a reduced set of continuous exposure indices based on commonly occurring exposures, while individuals who share similar exposure profiles or "exposomes" will be defined.
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Findings from a recent large study suggest that perchlorate at commonly occurring exposure concentrations may decrease thyroid hormone levels in some women.
However, the magnitude of risk per unit dose depends strongly on when radiation exposure occurs: exposure before the age of 20 years carries the greatest risk.
With our approach in verifying a previously occurred exposure with P. acnes in vivo, we were able to abrogate this experimental limitation.
Finally, chemical exposures may have substantially different health consequences for children depending on the developmental stage during which the exposure occurs, requiring exposure characterization at multiple time points.
Reliable data on effects (lack of) associated with naturally occurring (background) exposures can sometimes provide considerable reassurance.
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