Just as for the RPG upstream regions, motifs 12 0 and 12 5 displayed the strongest co-occurrence tendency; the two motifs had similar individual frequency counts and co-occurred for about one-third of their instances.
In this study, we introduced a new measure for regulatory motif co-occurrence, and investigated genome-wide co-occurrence tendencies between pairs of regulatory motifs.
From these, a FR(B|A) sampled is calculated, reflecting the genome wide co-occurrence tendencies of the pair of motifs.
Applying this measure on the TFBSs in the genomic set of human and mouse promoters, we observed how co-occurrence tendencies are strikingly different between promoters with high GC content and CpG scores and promoters with low GC content and CpG scores, with the latter having a higher variety in FR values.
In order to obtain a measure of statistical significance, we compare the observed FR values for pairs of motifs in a set of co-expressed genes with those of sets of genes sampled at random, thus taking into account biases caused by genome-wide co-occurrence tendencies.
The Likert scale can also prevent the occurrence of central tendency errors.
The four-point rating scale was chosen to prevent the occurrence of central tendency error.
Flow cytometry parameters recorded 48 h after admission were not associated with sepsis occurrence, although a tendency (P < 0.10) remained for platelet-Fg (data not shown).
This finding would be valuable to evaluate the tendency on occurrence of floods and droughts in the Pearl River basin, a humid region, which may be transferable to other basins in the globe.
They define a "fragility" score for a pattern's occurrence that reflects the tendency of its constituting genes to be uniformly present or absent in an ensemble of 4 related organisms.
