The clinical use of these drugs involves some problems related to their low solubility and occurrence of resistance, which is mainly dependent on the multidrug-resistant (MDR) phenotype.
For insect-resistant GM maize, the aim is to prevent the occurrence of resistance in the respective target organisms, thereby defining a damage threshold.
(iv) The substitution does not compromise resistance management and the minimisation of the occurrence of resistance.
Subsequently, intervention strategies could be designed to minimize the occurrence of resistance.
The importance of the gatekeeper and pyrazole-glycine interactions are highlighted by the occurrence of resistance via mutation at these sites [93].
Combination strategies in the first-line treatment have been studied most to improve the benefit from EGFR TKI monotherapy and delay the occurrence of resistance.
The lack of novel antimicrobial drugs under development coupled with the increasing occurrence of resistance to existing antibiotics by community and hospital acquired infections is of grave concern.
Simultaneous administration of both inhibitors considerably decreased occurrence of resistance in a dose-dependent manner.
Isolates with an intermediate phenotype were interpreted as susceptible in order to not over-estimate the occurrence of resistance.
Therefore, we concluded that both SA and Ca2+ signaling are primary concurrent signaling events important for the occurrence of resistance.
Occurrence of resistance secondary to treatment with tyrosine kinase inhibitors complicates treatment of CML and is the major cause of disease relapse in the course of therapy.
