Sentence examples for occurrence of alterations from inspiring English sources

Much scientific evidence, however, supports the occurrence of alterations in red cells over their storage time, and observational studies suggest that transfusion of older RBC may have important adverse clinical consequences, including mortality in this population.

In the present study, the occurrence of alterations was closely related to the age of males.

Therefore, the aim of this study was to determine the occurrence of alterations of these TACCs in ovarian cancer.

In addition, in the present study, treatment with insulin prevented the occurrence of alterations caused by diabetes, i.e. bradycardia, hypotension and low +dP/dtmax and low -dP/dtmax.

The loss of genomic stability appears to be a key molecular and pathogenetic step occurring early in tumourigenesis creating a permissive environment for the occurrence of alterations in tumour suppressor genes and oncogenes [ 3].

Thus, based upon both the location of TACC1 and TACC3 in regions consistently associated with ovarian cancer [ 3, 5] and SAGE expression data [ 6], we have set out to determine the occurrence of alterations of these TACCs in ovarian cancer.

HPLC-DAD analyses were carried-out to verify the occurrence of alteration of chromatographic profiles during the drying the operation.

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types.

The last result makes sense because all the genetic alterations detected in the regenerants should have occurred at the callus stage while the occurrence of epigenetic alterations is not confined to the callus phase but also in the regeneration process, due to developmental dynamics of DNA methylation patterns in plants [ 13].

Remodeling of donor chromatin by the recipient cytoplasm after nuclear transfer is frequently associated with the deregulation of specific genes, and recent observations point to the potential importance of time-dependent DNA methylation events in the occurrence of these alterations.

By exploiting both gene profiling and activated kinases arrays, we could demonstrate the occurrence of important alterations in the level of expression and activation of a few mediators from the PI3K/Akt and CREB pathways in response to the ECM remodeling taking place during wound healing of damaged hTECs.